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KMID : 1140120070120010030
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Cancer Prevention Research
2007 Volume.12 No. 1 p.30 ~ p.34
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Curc umin, Indomethac in, and Naproxen Synergistic ally Inhibit the Growth of Human Colorec tal Canc er Cells (HT-29)
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Yuan Hai-Dan
Park Jin-Hee
Kang Ju-Seop
Hong Jung-Wook
Lim Su-Jin
Oh Hyun-Yin
Kim Hyun-Jin
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Abstract
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The aim of this study was to investigate the effect of curcumin, indomethacin, curcumin and naproxen combination synergistically on the growth of HT-29 cells. The growth of HT-29 cells were examined by MTS cell viability assay by one to four days treatment with curcumin (10∼50 uM), indomethacin (250∼1,000 uM), curcumin (10∼50 uM) and naproxen (250∼1,000 uM) to 2×104 HT-29cells/mL. The results suggested that curcumin inhibited the growth of HT-29 cells in a dose-dependent fashion. In concentration range from 500 to 1,000 uM, indomethacin was inhibitied the growth of HT-29 cells in a dose - dependent fashion. To examine inhibitory effects of curcumin and indomethacin, curcumin and
naproxen combinination on the HT-29 cell lines, we treatment with 20 uM curcumin and indomethacin (500 uM, 750 uM) combinination curcumin and naproxen (750 uM, 1,000 uM) combinination to 2×104 HT-29 cells/well. The results suggested that curcumin potentiates the inhibitory effect of indomethacin on the growth of HT-29 cell lines by shifting the dose-dependent manner. (Cancer Prev Res 12, 30-34, 2007)
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KEYWORD
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Curcumin, Indomethacin, Naproxen, HT-29, Colon cancer
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